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September 23, 2025NEJM Evidence

Peri–Covid-19 Antibiotic Use and Antimicrobial Resistance in Older Adults

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Authors

DMDerek R. MacFaddenCMColleen J. MaxwellDBDawn M. E. Bowdish

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Overview

Cohort study evaluates antibiotic use and the prevalence of antimicrobial resistance in older adults during Covid-19.

Key Points

  • Antibiotic use during the Covid-19 pandemic was linked to antimicrobial resistance, particularly in older adults.
  • In the cohort of 53,533 older adults, 15% received antibiotics peri-Covid-19, with 3% showing resistance.
  • The adjusted odds ratio for antibiotic-resistant organisms with antibiotic use was 1.24, indicating a significant association.
  • Increased antimicrobial resistance was particularly noted for gram-negative organisms, highlighting a serious concern.

Cite This Study

MacFadden et al. (2025) studied this question.

synapsesocial.com/papers/68d440a6713b0b5dfea7ff23https://doi.org/10.1056/evidoa2400108
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