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September 23, 2025NEJM Evidence

Pharmacogenetic Testing — Evidence, Challenges, and Pathways to Adoption

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Authors

NRNihal El RoubyJJJulie A. Johnson

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Overview

Observational analysis highlights challenges in implementing pharmacogenetic testing in clinical practice, indicating the need for improved clinician training.

Key Points

  • Clinical pharmacogenetic testing can optimize drug selection and dosing, enhancing treatment effectiveness.
  • Evidence from the past decade has identified many pharmacogenetic associations across various medical specialties.
  • Challenges such as clinician confidence and reimbursement issues hinder broader adoption of pharmacogenetic testing.
  • Future strategies include using multigene panels and integrating pharmacogenetic data into electronic health records.

Cite This Study

Rouby et al. (2025) studied this question.

synapsesocial.com/papers/68d440a6713b0b5dfea7ff1ehttps://doi.org/10.1056/evidra2400343
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genotype-guided pharmacotherapy: the challenges of integrating pharmacogenomic testing into routine healthcare with a focus on experiences at a single site.2025
  2. 2Pharmacogenomics in Clinical Practice: Towards a Personalized Drug Therapy Paradigm2025
  3. 3Patient and clinician perspectives on pharmacogenetic testing for antipsychotics2025 · 4 citations
  4. 4Pharmacogenomics Applications in Clinical Practice: Revolutionizing Patient Care2025
  5. 5Implementing pharmacogenetic testing in community pharmacy practice: a scoping review2025