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September 23, 2025Frontiers in ImmunologyOpen Access

Identification of tumor associated neutrophils-related genes in triple-negative breast cancer for predicting prognosis and therapeutic response through integrated single-cell analysis

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Authors

KLKoukou LiLGLingli GongYZYuxuan Zhang

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Overview

Integrated analysis uncovers tumor-associated neutrophils' roles in TNBC, suggesting novel therapeutic targets.

Key Points

  • Elevated expression of RASGRP4 and TIMM10B, along with lower TNFRSF13C, correlates with poor survival in TNBC.
  • Four TAN-associated genes were identified, with RASGRP4 and TIMM10B showing pro-tumor effects, while TNFRSF13C shows tumor-suppressive properties.
  • Comprehensive analysis utilized single-cell RNA-seq data and various bioinformatics techniques to elucidate gene functions.
  • Targeting identified genes could disrupt pro-tumor immune responses, highlighting potential new strategies to improve outcomes for TNBC patients.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d440a6713b0b5dfea7feb8https://doi.org/10.3389/fimmu.2025.1613529
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