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September 23, 2025Strahlentherapie und OnkologieOpen Access

Locally advanced breast cancer: primary ultra-hypofractionated radiotherapy for inoperable or frail patients

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Authors

AKAnne Caroline KnöchelmannMedizinische Hochschule HannoverRMRoland MertenMedizinische Hochschule HannoverHCHans ChristiansenOrganisation de Coopération et de Développement Economiques

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Implication

Retrospective analysis found effective treatment in inoperable patients, suggesting ultra-hypofractionation is beneficial.

Key Points

  • Ultra-hypofractionation resulted in a clinical response in 56% of patients treated for advanced breast cancer.
  • Patients received a median of 25 Gy with an integrated boost of 30 Gy, showing no high-grade toxicity.
  • A total of 29 patients aged 82 years underwent radiotherapy, evaluated for outcomes and safety.
  • The study indicates that five fractions of this regimen can be a safe and effective palliative approach.

Cite This Study

Knöchelmann et al. (2025) studied this question.

synapsesocial.com/papers/68d440a6713b0b5dfea7fdb2https://doi.org/10.1007/s00066-025-02445-5
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Long-Term Results of Hypofractionated Radiation Therapy for Breast Cancer2010 · 1,899 citations