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September 23, 2025

Synergistic protective effects of β-glucan and

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Authors

SZShanshan ZhangYSYonggan SunLGLinlin Gao

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Overview

This study demonstrates the protective effects of a novel synbiotic, β-glucan and Lactobacillus johnsonii, in ulcerative colitis, indicating its potential as a new therapeutic option.

Key Points

  • BGLJ treatment significantly mitigated DSS-induced weight loss and reduced disease activity.
  • Notably, BGLJ markedly increased Lactobacillus johnsonii populations in fecal samples.
  • BGLJ elevated indole-3-lactic acid levels, activating AhR and enhancing IL-22 production.
  • The findings highlight BGLJ's potential in maintaining intestinal homeostasis in ulcerative colitis.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68d4409f713b0b5dfea7fa3fhttps://doi.org/10.1039/d5fo02391b
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