Association of exposure to phenols, pesticides, and phthalates with hepatic steatosis and MASLD in adolescents: the potential role of inflammation and lifestyle factors

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Exposure to phenols, pesticides, and phthalates is significantly associated with hepatic steatosis or MASLD.
Among 2,163 adolescents, 490 (22.7%) were diagnosed with MASLD, highlighting a prevalent metabolic concern.
Mediation analysis revealed that white blood cells partially mediate the effects of chemical exposure on MASLD.
Lifestyle factors, including sedentary behavior and physical activity, influence the impact of chemical mixtures on MASLD.

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Analysis reveals significant associations between phenols, pesticides, phthalates, and MASLD, suggesting inflammation's role.

Yao et al. (2025) studied this question.

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