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September 23, 2025Open Access

Comparative Efficacy and Safety of Left Atrial Appendage Occlusion Versus Direct Oral Anticoagulants in Atrial Fibrillation: A Systematic Review and Meta-Analysis

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Authors

MJManish JunejaDPDeep PatelMGMartin Gärde

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Overview

Systematic review found comparable efficacy for LAAO and DOACs in stroke prevention, indicating viability for high-risk AF patients.

Key Points

  • LAAO shows comparable stroke prevention to DOACs in patients with atrial fibrillation, without significant differences in outcomes.
  • Meta-analysis indicated no notable differences in mortality or bleeding complications between LAAO and DOACs across 14 studies.
  • The study included 683,659 patients overall, with a focus on thromboembolic outcomes and risk of bias assessments.
  • LAAO may be a suitable option for patients with atrial fibrillation at high risk for bleeding or contraindicated for long-term anticoagulation.

Cite This Study

Juneja et al. (2025) studied this question.

synapsesocial.com/papers/68d43ee5713b0b5dfea7edeahttps://doi.org/10.1101/2025.09.21.25336272
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Left atrial appendage occlusion: real world observational data on in-hospital results, clinical outcome and hemoglobin level2025 · 1 citations