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September 23, 2025Oncology LettersOpen Access

Prognostic value of M2 macrophage‑related genes and their importance in the immunotherapy response in hepatocellular carcinoma

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Authors

AWAiping WangXLXiaojing LiZWZi Wang

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Overview

Bioinformatics analysis reveals M2 macrophage-related genes predicting immune therapy responses in LIHC, suggesting potential for targeted therapies.

Key Points

  • The prognostic model identifies M2 macrophage-related genes that predict overall survival in hepatocellular carcinoma patients.
  • High-risk patients exhibited markedly worse overall survival rates compared to low-risk individuals, indicating significant predictive power.
  • Bioinformatics analysis allowed the identification of key prognostic biomarkers like KLRB1 related to immune infiltration in the tumor microenvironment.
  • Inhibition of KLRB1 increased macrophage polarization towards the M2 phenotype, which could impact therapeutic strategies.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d43ee5713b0b5dfea7ec2fhttps://doi.org/10.3892/ol.2025.15286
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