Modelling the relative contribution of infection, routine vaccination and supplementary immunisation activities to measles seroconversion in Kenyan Children
Mathematical modeling estimates the impact of vaccination and infection on measles immunity in children, suggesting critical insights for public health planning.
Key Points
Approximately 60% of measles seroconversion in Kilifi is attributable to the first dose of measles-containing vaccine (MCV1), highlighting vaccine effectiveness.
A hypothetical 10% boost in MCV1 coverage could raise seroconversion from MCV1 to 67%, while diminishing reliance on supplementary immunisation activities.
Natural infection accounted for 24% of seroconversion, indicating ongoing challenges in measles immunity and infection risk in children.
Optimal vaccination timing and coverage can reduce dependency on supplementary immunisation activities, underscoring the importance of timely vaccine administration.