September 23, 2025Veterinary Dermatology

Clinical, Histopathological and Molecular Characterisation of Canine Epitheliotropic Cutaneous T‐Cell Lymphoma With Cytotoxic Interface Dermatitis: A Retrospective Case Series

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Authors

LSLynn Smith FBFrane BanovićUniversity of Georgia MPMarlene S Pariser

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Implication

Retrospective case series identifies novel cytotoxic variant in canine epitheliotropic cutaneous T-cell lymphoma, highlighting importance of immunohistochemical and clonality analysis.

Key Points

Histopathological examination confirmed a cytotoxic pattern of epitheliotropic cutaneous T-cell lymphoma.
All six cases exhibited strong CD3+ T-cell immunoreactivity, indicating significant T-cell presence in skin tissues.
Clonality testing for T-cell receptor gene showed all cases to be positive, confirming disease specificity.
Clinical symptoms included severe skin lesions with apoptosis and lymphocytic infiltrates observed in affected dogs.

Cite This Study

Smith et al. (2025) studied this question.

synapsesocial.com/papers/68d43ed7713b0b5dfea7e3ca https://doi.org/10.1111/vde.70029

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Implication

Retrospective case series identifies novel cytotoxic variant in canine epitheliotropic cutaneous T-cell lymphoma, highlighting importance of immunohistochemical and clonality analysis.

Clinical, Histopathological and Molecular Characterisation of Canine Epitheliotropic Cutaneous T‐Cell Lymphoma With Cytotoxic Interface Dermatitis: A Retrospective Case Series

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Key Points

Cite This Study

Clinical, Histopathological and Molecular Characterisation of Canine Epitheliotropic Cutaneous T‐Cell Lymphoma With Cytotoxic Interface Dermatitis: A Retrospective Case Series

Discussion

Member takes

Implication

Key Points

Cite This Study

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