Promising Targets and Drugs for Improving Head and Neck Cancer Response to Radiotherapy

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This review highlights mechanisms of radioresistance in head and neck cancers, suggesting potential targets for radiosensitization.

Recent findings highlight that understanding the tumor microenvironment can improve head and neck cancer treatment responses.
Effective radiosensitization strategies may arise from targeting DNA damage response and immune modulation mechanisms.
The interplay between stromal and immune components in the tumor microenvironment significantly influences treatment resistance.
Radiosensitization could be achieved by addressing pathways affected by human papillomavirus and metabolic remodeling.

Muhammad et al. (2025) studied this question.

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