Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 23, 2025Anaesthesia Pain & Intensive CareOpen Access

Comparative study of clonidine and fentanyl as adjuvants to ropivacaine in spinal anesthesia: impact on analgesic efficacy, hemodynamic stability, and adverse effects

View Full Paper
Ask AI
Bookmark
Share

Authors

VSV A SabapathyLALakshmi AmbaliPTPrabhu Thilaak

Discussion

Loading...

Member takes

Overview

Randomized trial compares analgesic efficacy and hemodynamic stability in patients undergoing spinal anesthesia, indicating clonidine offers prolonged blockade but with more adverse effects.

Key Points

  • Clonidine significantly prolonged sensory and motor blockade compared to fentanyl and ropivacaine alone.
  • Time to first rescue analgesia was 528.8 minutes for clonidine, significantly longer than fentanyl's 422.1 minutes or ropivacaine's 203.3 minutes.
  • Hemodynamic instability featured prominently in the clonidine group, with increased hypotension and bradycardia incidents.
  • Fentanyl improved analgesia with lower hypotension risk but had higher bradycardia incidence than ropivacaine.

Cite This Study

Sabapathy et al. (2025) studied this question.

synapsesocial.com/papers/68d43ed1713b0b5dfea7e017https://doi.org/10.35975/apic.v29i6.2903
View Full Paper
Ask AI
Bookmark
Share