Use of Oral Antibiotics for Diabetic Foot Osteomyelitis: A Systematic Review

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Systematic review evaluates oral antibiotics' outcomes in diabetic foot osteomyelitis, suggesting effective treatment options.

Oral antibiotic therapy achieves 75.2% complete resolution in diabetic foot osteomyelitis cases when used alone, indicating effectiveness.
In a systematic review of 26 studies, 972 patients showed various outcomes for oral antibiotics, including 5.4% recurrence with monotherapy.
Patients experienced 21.6% cases of unresolved diabetic foot osteomyelitis with oral therapy alone, emphasizing the need for adherence.
Findings suggest oral antibiotics can be a viable option, especially in low-resource settings, while cautioning against antibiotic resistance.

Sood et al. (2025) studied this question.

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