Naringenin nanoparticles show anti-angiogenic activity in HUVECs and a chick chorioallantoic membrane model and anticancer activity in MCF-7 cells

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Nanoparticles of naringenin reduce cell viability in MCF-7 cells and inhibit angiogenesis in HUVECs, suggesting potential therapeutic applications.

Naringenin nanoparticles effectively reduced cell viability and migration in both MCF-7 and HUVEC cells.
Molecular docking confirmed strong binding affinity of naringenin to VEGF, indicating potential as an anti-angiogenic agent.
Analysis revealed significant downregulation of pro-angiogenic and inflammatory markers associated with angiogenesis.
Chick chorioallantoic membrane model demonstrated decreased blood vessel density and total branching, supporting the anti-angiogenic effects.

Yasam et al. (2025) studied this question.

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Nanoparticles of naringenin reduce cell viability in MCF-7 cells and inhibit angiogenesis in HUVECs, suggesting potential therapeutic applications.