Predictive value of 8-hydroxy-2′-deoxyguanosine and 8-nitroguanine production in radiation-induced skin damage after postoperative breast cancer radiotherapy

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This observational analysis reveals correlations between 8-OHdG and 8-NG with radiation toxicity, suggesting their predictive roles in skin damage.

A significant correlation exists between 8-OHdG and 8-NG levels and skin toxicity after radiotherapy, indicating their predictive value.
Statistical analysis demonstrated an important relationship between radiation doses and the severity of skin toxicity (p < 0.05).
Data was collected from 33 breast cancer patients receiving adjuvant radiotherapy to evaluate DNA adduct levels.
These findings suggest that monitoring 8-OHdG and 8-NG may help predict radiation-induced skin damage.

Verigos et al. (2025) studied this question.

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This observational analysis reveals correlations between 8-OHdG and 8-NG with radiation toxicity, suggesting their predictive roles in skin damage.