September 23, 2025Journal of Diabetes ResearchOpen Access

Single‐Cell RNA Sequencing Shows Exercise Protects db/db Mouse Pancreatic Injuries by Regulating Endothelial Cell Homeostasis

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This study demonstrates exercise improves pancreatic function in db/db mice, regulating endothelial cells and their proliferation.

Exercise improved the body weight and pancreatic profile of db/db mice, showing a significant protective effect.
Single-cell RNA sequencing revealed changes in endothelial cells among 12 pancreatic cell types in db/db mice.
Five subtypes of endothelial cells were identified, with capillary ECs showing significant differences linked to exercise.
Gene Ontology analysis suggested specific roles of endothelial cell subtypes in regulating proliferation and response to injury.

Weng et al. (2025) studied this question.

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September 23, 2025Journal of Diabetes ResearchOpen Access

View Full Paper

Ask AI

Bookmark

Authors

This study demonstrates exercise improves pancreatic function in db/db mice, regulating endothelial cells and their proliferation.

Exercise improved the body weight and pancreatic profile of db/db mice, showing a significant protective effect.
Single-cell RNA sequencing revealed changes in endothelial cells among 12 pancreatic cell types in db/db mice.
Five subtypes of endothelial cells were identified, with capillary ECs showing significant differences linked to exercise.
Gene Ontology analysis suggested specific roles of endothelial cell subtypes in regulating proliferation and response to injury.

Weng et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark