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September 20, 2025American Journal of OphthalmologyOpen Access

Longitudinal neural and microvascular changes in type 2 diabetic patients without retinopathy: a 2-year prospective cohort study

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Authors

YFYiran FanLLLingyi LiXWXinyan Wu

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Overview

Prospective cohort study shows reduced GCIPLT in type 2 diabetes patients without retinopathy, suggesting early monitoring. Longitudinal changes indicate neurodegeneration precedes microvascular issues.

Key Points

  • Significant reductions in GCIPLT were observed in non-DR patients, indicating accelerated neurodegeneration.
  • GCIPLT decreased by -0.229 μm/year in non-DR patients, approximately 5-fold compared to healthy controls.
  • Linear mixed-effects models were utilized to assess changes across both groups over two years.
  • Monitoring GCIPLT is crucial for managing neurodegenerative changes in long-standing diabetes, even without retinopathy.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/68d43c87713b0b5dfea7c538https://doi.org/10.1016/j.ajo.2025.09.025
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