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September 20, 2025EpigenomesOpen Access

m6A RNA Methylation in Psychiatric Disorders: An Emerging Epitranscriptomic Axis

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Authors

ANA. NgoLNLinda NguyenNANiki Gharavi Alkhansari

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Overview

This review highlights m6A regulation's roles in gene expression in psychiatric disorders, suggesting implications for neural plasticity.

Key Points

  • Aberrant m6A regulation is linked to various psychiatric disorders including depression and anxiety, revealing new insights into their pathophysiology.
  • Key mechanisms governing m6A include specific methyltransferases and demethylases that modulate neuronal differentiation and memory formation.
  • This review utilizes an epitranscriptomic approach to enhance understanding of m6A's impact on neural homeostasis and psychiatric health.
  • Further investigations into m6A function may support advancements in therapeutic strategies aimed at enhancing cognitive resilience and mental health.

Cite This Study

Ngo et al. (2025) studied this question.

synapsesocial.com/papers/68d43c87713b0b5dfea7c49ehttps://doi.org/10.3390/epigenomes9030036
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Also Consider

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  1. 1Crosstalk Between N6-Methyladenosine and Other Epigenetic Mechanisms in Central Nervous System Development and Disorders2025
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  5. 5Epigenetic regulation in cognitive impairment: Focus on N6‐methyladenosine modification and its potential role in perioperative neurocognitive disorders2025