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September 20, 2025Journal of the American Heart AssociationOpen Access

Presence of Clonal Hematopoiesis and Cardiac Events After Allogeneic Stem Cell Transplantation

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Authors

CQCooper QuartermaineZBZachary BraunsteinASAdnan Shaaban

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Overview

Prospective analysis finds increased atrial fibrillation rates in patients with clonal hematopoiesis after allogeneic transplantation, suggesting cardiac risk.

Key Points

  • Clonal hematopoiesis significantly increases the risk of atrial fibrillation in patients post-stem cell transplantation, highlighting a critical cardiac risk factor.
  • During a median follow-up of 35 months, 11.5% of patients developed incident atrial fibrillation, markedly higher than predicted rates from Framingham.
  • Multivariable regression identified an increased hazard ratio of 4.0 for atrial fibrillation with higher clonal hematopoiesis burden, indicating strong association.
  • Major adverse cardiac events occurred in 29.9% of patients, emphasizing the necessity for monitoring cardiac health in these populations.

Cite This Study

Quartermaine et al. (2025) studied this question.

synapsesocial.com/papers/68d43c87713b0b5dfea7c3dfhttps://doi.org/10.1161/jaha.124.039977
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