September 20, 2025Non-Coding RNAOpen Access

Long Non-Coding RNAs in Psoriasis: A Comprehensive Review of Expression Profiles, Mechanistic Insights, Genetic Associations, and Their Clinical Implications

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Long non-coding RNAs significantly influence psoriasis pathogenesis through abnormal keratinocyte regulation, promoting hyperproliferation and inflammatory responses.
Key lncRNAs such as MALAT1 and HOTAIR are upregulated in psoriatic lesions, offering insights into the role of lncRNAs in chronic inflammatory processes.
Genetic variants in lncRNA regions are linked to psoriasis susceptibility, with population-specific associations providing potential pharmacogenomic markers.
Integrating lncRNA profiling into clinical practice may enhance understanding of psoriasis variability and improve treatment outcomes for patients.

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This review highlights gene expression profiles and genetic associations of long non-coding RNAs in psoriasis, indicating new mechanistic insights.

Danis et al. (2025) studied this question.

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This review highlights gene expression profiles and genetic associations of long non-coding RNAs in psoriasis, indicating new mechanistic insights.