September 19, 2025PeerJOpen Access

Expression characterization of the guanylate-binding protein gene family in breast cancer and its association with the immune microenvironment

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Discussion

Observational analysis found links between immune microenvironment and GBP scores in breast cancer, suggesting new prognostic avenues.

Low guanylate-binding protein scores are significantly linked to poorer overall survival in breast cancer patients.
Key prognostic genes, including DACT2, PSME2, PIGR, and STX11, were identified and used to build a risk model.
In vitro experiments confirmed that overexpression of DACT2 suppressed the survival and migration of breast cancer cells.
The study highlights the connection between GBP-related genes and immune cell infiltration in breast cancer prognosis.

Wei et al. (2025) studied this question.

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