Systematic review evaluates antibiotic resistance trends in uropathogens from patients with recurrent urinary tract infections, highlighting significant challenges in treatment.
Key Points
High prevalence of multidrug-resistant uropathogens complicates the management of recurrent urinary tract infections.
Resistance rates to fluoroquinolones often exceed 50%, and to third-generation cephalosporins can reach up to 65% in Escherichia coli and Klebsiella pneumoniae.
Older antibiotics like nitrofurantoin and fosfomycin remain effective, with resistance rates generally below 10% against most E. coli isolates.
Emphasizing the need for culture-guided treatment, the results indicate increasing reliance on older agents to combat antibiotic resistance.