Immune microenvironment-dependent effects of age-associated Bifidobacterium strains on gut immunity and microbial diversity

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Both Bifidobacterium adolescentis and Bifidobacterium longum subsp. infantis influence gut immunity and microbial diversity.
Transcriptomic analysis showed differential gene expression, particularly affecting cytokine signaling pathways.
Direct co-culture experiments indicated significant activation of γδ T cells by Bifidobacterium longum subsp. infantis.
Findings support personalized probiotic strategies that could enhance immune health and gut homeostasis.

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Study reveals how Bifidobacterium strains modulate gut immunity and microbial diversity, suggesting therapeutic implications.

He et al. (2025) studied this question.

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