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September 16, 2025PathophysiologyOpen Access

Serial Anti-GM-CSF Autoantibody Levels Reflect Disease Activity in Hypersensitivity Pneumonitis with Autoimmune Pulmonary Alveolar Proteinosis: Case Report

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Authors

TAToru AraiNHO Kinki Chuo Chest Medical CenterMHMasaki HiroseNHO Kinki Chuo Chest Medical CenterESEiji SugimotoNHO Kinki Chuo Chest Medical Center

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Implication

Case report demonstrates changes in GM-CSF autoantibody levels in hypersensitivity pneumonitis, suggesting potential therapeutic insights.

Key Points

  • GM-CSF autoantibody levels correlate with disease activity in hypersensitivity pneumonitis and aPAP.
  • Increased GMAb levels were observed at disease onset, indicating a potential role in monitoring treatment responses.
  • The patient experienced multiple relapses, showing variable GMAb levels in response to oral prednisolone therapy.
  • Autoimmune pulmonary alveolar proteinosis may complicate hypersensitivity pneumonitis, highlighting the need for careful management.

Cite This Study

Arai et al. (2025) studied this question.

synapsesocial.com/papers/68d43c79713b0b5dfea7bc21https://doi.org/10.3390/pathophysiology32030047
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