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September 16, 2025Journal of Hepatocellular CarcinomaOpen Access

TACE-HAIC versus TACE as Initial Regional Therapy for Unresectable Huge Hepatocellular Carcinoma (>10 cm): A Propensity Score-Matched Study

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Authors

CLChong LiuJLJing LiMZMing Zhao

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Overview

Propensity score-matched study reveals TACE-HAIC significantly improves survival in unresectable HCC, suggesting a superior approach compared to TACE.

Key Points

  • TACE-HAIC significantly increased objective response to 74.0% compared to 58.4% for TACE, indicating better treatment effectiveness.
  • Median progression-free survival for patients treated with TACE-HAIC was 12.3 months, compared to 7.4 months with TACE, highlighting its efficacy.
  • Patients in Barcelona Clinical Liver Cancer stage C experienced notably longer overall survival in the TACE-HAIC group, demonstrating treatment benefits.
  • TACE-HAIC therapy exhibited an acceptable safety profile with fewer severe adverse events compared to TACE alone, supporting its clinical use.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d43b18713b0b5dfea7bb4ehttps://doi.org/10.2147/jhc.s537950
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