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September 20, 2025Age and Ageing

Effects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial

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Authors

SLSidong LiRHRikuta HamayaHZHaidong Zhu

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Overview

Randomized trial showed cocoa extract reduced hsCRP in older adults, suggesting inflammatory modulation.

Key Points

  • Cocoa extract supplementation significantly decreased hsCRP levels compared to placebo, indicating inflammatory benefits.
  • Participants receiving cocoa extract exhibited a yearly reduction in hsCRP of 8.4%, supporting its anti-inflammatory effects.
  • Cocoa extract increased IFN-γ levels with a 6.8% yearly change versus placebo, highlighting need for further investigation.
  • These findings suggest cocoa extract may play a role in reducing cardiovascular disease risk among older adults.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68d43a00713b0b5dfea7a2c8https://doi.org/10.1093/ageing/afaf269
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