September 20, 2025The Journal of ImmunologyOpen Access

Transcriptional states of lung cancer microenvironment reveal macrophage subtype dynamics linked to disease progression

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Increased lipid-associated TAMs correlates with advanced lung cancer and poor prognosis, enhancing understanding of tumor progression.
Seven distinct macrophage subtypes were identified using single-cell RNA sequencing and spatial transcriptomics, revealing diverse functions.
The study conducted comprehensive analyses across large cohorts, utilizing clinical datasets to deepen insights into immune dynamics in lung cancer.
The findings support the potential of lipid-associated TAMs as biomarkers and therapeutic targets in lung cancer treatment.

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Integrative analysis identifies macrophage subtype dynamics in lung cancer, suggesting potential biomarkers and therapeutic targets.

Keremitçi et al. (2025) studied this question.

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