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September 20, 2025Nephrology Dialysis TransplantationOpen Access

Characteristics and cardio-renal outcomes in CKD patients receiving guideline-directed therapy: insights from DISCOVER CKD

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Authors

RPRoberto Pecoits–FilhoEKEiichiro KandaNKNaoki Kashihara

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Overview

Observational cohort study finds GDMT reduces adverse renal outcomes in CKD patients, indicating it could improve long-term health.

Key Points

  • GDMT use was associated with a 52% lower incidence of adverse renal outcomes in CKD patients, highlighting its value.
  • In a cohort of 1052 patients, 61.1% received GDMT, with varying rates across countries, emphasizing implementation disparities.
  • The study employed inverse probability treatment weighting to control for confounding and estimate GDMT effects on outcomes.
  • Significant gaps in GDMT implementation were observed, calling for improved strategies to enhance patient care.

Cite This Study

Pecoits–Filho et al. (2025) studied this question.

synapsesocial.com/papers/68d439fa713b0b5dfea79ea5https://doi.org/10.1093/ndt/gfaf175
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