Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 20, 2025Current Drug Metabolism

Transfer of Intravenous Remimazolam into Milk of Lactating Sheep and Uptake by Breast-fed Lambs

View Full Paper
Ask AI
Bookmark
Share

Authors

WSWolfgang A. SchmalixMOMaureen OnyuroMPMarija Pesic

Discussion

Loading...

Member takes

Overview

Animal study shows remimazolam transfers to milk and affects lamb sedation, suggesting minimal breastfeeding risk.

Key Points

  • Remimazolam concentrations in milk were higher than in plasma, indicating significant transfer during lactation.
  • The study recorded a mean plasma Cmax of 278.3 ng/mL after intravenous administration in lambs, highlighting effective transfer.
  • Lambs experienced varying sedation levels by intravenous remimazolam, fully reversible within 8 to 15 minutes after treatment.
  • Oral remimazolam resulted in negligible plasma levels, suggesting low risks for breastfed infants when nursing interruption occurs.

Cite This Study

Schmalix et al. (2025) studied this question.

synapsesocial.com/papers/68d439fa713b0b5dfea79d26https://doi.org/10.2174/0113892002372645250910083616
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rethinking remimazolam: reconciling regulatory positioning with clinical reality2026
  2. 2Pharmacokinetics of Remimazolam Versus Midazolam After Intravenous Administration to Horses2025
  3. 3Remimazolam besylate in intravenous conscious sedation for dental treatment: a prospective cohort study2025
  4. 4Remimazolam in pediatric anesthesia: a systematic review for clinical decision-making2025
  5. 5Remimazolam Enables Faster Sedation Induction and Recovery Compared With Midazolam in Diagnostic Upper Gastrointestinal Endoscopy: A Multicenter Randomized Controlled Trial2025