September 20, 2025Frontiers in PharmacologyOpen Access

Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes: a Bayesian network meta-analysis

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Discussion

Bayesian network meta-analysis compares gastrointestinal adverse effects in type 2 diabetes patients, highlighting GLP-1RA differences.

Tirzepatide has the highest risk of gastrointestinal adverse effects in patients with type 2 diabetes.
Nausea has a total incidence of 21.49% among gastrointestinal adverse events, which are common in this patient group.
Bayesian network meta-analysis was employed to assess the gastrointestinal adverse effects of GLP-1 receptor agonists.
Findings support individualized treatment strategies based on the tolerability of gastrointestinal side effects.

Xie et al. (2025) studied this question.

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