September 20, 2025PeerJOpen Access

Uric acid to HDL cholesterol ratio as a novel predictor of carotid intima-media thickness: a cross-sectional study in rural China

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Discussion

Cross-sectional study finds uric acid to HDL cholesterol ratio predicts carotid thickness, indicating cardiovascular risk in older adults.

Uric acid to HDL cholesterol ratio significantly predicts carotid intima-media thickness, especially in older men.
Multivariate analysis identified UHR as an independent risk factor for increased cIMT with β = 0.06 (95% CI [0.01–0.10], P = 0.017).
ROC analysis revealed UHR's predictive value for cIMT thickening is higher than that of SUA or HDL-C alone.
Subgroup analysis highlighted stronger associations between UHR and cIMT in participants aged 60 or older and males.

Luo et al. (2025) studied this question.

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Cross-sectional study finds uric acid to HDL cholesterol ratio predicts carotid thickness, indicating cardiovascular risk in older adults.