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September 20, 2025Frontiers in PharmacologyOpen Access

Therapeutic potential of natural medicines in diabetic kidney disease: restoring lipid homeostasis via lipophagy modulation

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Authors

JGJunwei GaoYWYunzhou WuXCXudong Cai

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Overview

Review reveals natural medicines improve lipid homeostasis in diabetic kidney disease, suggesting new therapeutic approaches.

Key Points

  • Natural medicines restore lipid homeostasis by addressing lipophagy, showing potential for diabetic kidney disease treatment.
  • Efficacy of natural medicines noted across various kidney disease models, enhancing renal lipophagy and reducing kidney injury.
  • Key signaling pathways affected include AMPK/mTOR and PPARα/γ, illustrating how these compounds modulate lipid metabolism.
  • Ongoing challenges include understanding molecular mechanisms and conducting robust clinical trials for effective treatment implementation.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68d4390d713b0b5dfea78d3dhttps://doi.org/10.3389/fphar.2025.1665339
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