Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 20, 2025Molecular BiomedicineOpen Access

Single-cell RNA sequencing identifies CD8Teff cell activation as a predictive biomarker in triple-negative breast cancer immunotherapy

View Full Paper
Ask AI
Bookmark
Share

Authors

LMLuhui MaoZZZebang ZhangYCYongjian Chen

Discussion

Loading...

Member takes

Overview

Analysis reveals CD8Teff cells predict treatment response in TNBC, suggesting CXCL13 modulates the tumor microenvironment.

Key Points

  • CD8Teff cell activation predicts therapy response in triple-negative breast cancer, enhancing personalized treatment approaches.
  • High expression of CXCL13 marks immune-active tumors, correlating with improved progression-free survival and overall survival.
  • Using single-cell RNA sequencing, the immune landscape of TNBC is characterized, highlighting the role of CD8Teff cells and immune interactions.
  • An artificial intelligence model for CD8Teff recognition achieved an area under the curve of 0.823, supporting its predictive capabilities.

Cite This Study

Mao et al. (2025) studied this question.

synapsesocial.com/papers/68d43906713b0b5dfea78a85https://doi.org/10.1186/s43556-025-00306-2
View Full Paper
Ask AI
Bookmark
Share