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September 20, 2025NutrientsOpen Access

Alfalfa Polysaccharide Alleviates Colitis by Regulating Intestinal Microbiota and the Intestinal Barrier Against the TLR4/MyD88/NF-κB Pathway

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Authors

SLShaokai LaMAMuhammad AbaidullahHLHao Li

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Overview

Observational analysis revealed alfalfa polysaccharide improved gut barrier in mice with ulcerative colitis, suggesting novel prebiotic effects.

Key Points

  • Alfalfa polysaccharide alleviated colitis symptoms in mice, restoring gut integrity and microbiota balance.
  • Improvement included increased IL-10 and IL-22 levels, coinciding with decreased pro-inflammatory cytokines TNF-α, IL-1β, and IL-6.
  • Assessment using various techniques highlighted the protective role of alfalfa polysaccharide against the TLR4/MyD88/NF-κB pathway.
  • These findings support potential use of alfalfa polysaccharide as a prebiotic treatment for ulcerative colitis.

Cite This Study

La et al. (2025) studied this question.

synapsesocial.com/papers/68d43906713b0b5dfea789f6https://doi.org/10.3390/nu17183001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Almond Polysaccharide Ameliorates DSS‐Induced Ulcerative Colitis in Mice by Restoring Intestinal Barrier Function and Modulating Gut Microbiota and SCFAs Metabolism2025 · 7 citations
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  3. 3Active ingredients isolated from Periplaneta americana L. inhibit the inflammation of the colonic mucosa and regulate the gut microbiota in DSS-induced ulcerative colitis in mice2025 · 2 citations
  4. 4Chinese Yam Polysaccharide Alleviates DSS-Induced Ulcerative Colitis After Antibiotic Pretreatment2026 · 2 citations
  5. 5Galactooligosaccharides Promote Gut Barrier Integrity and Exert Anti-Inflammatory Effects in DSS-Induced Colitis Through Microbiota Modulation2025 · 3 citations