September 20, 2025Advanced ScienceOpen Access

NRF2‐REGγ‐ACADM/KLF15 Signaling Pathway Regulates the Browning of White Adipose Tissue to Modulate Obesity

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Discussion

Observational findings reveal REGγ's role in browning white adipose tissue, suggesting it may be a target for obesity intervention.

Inhibition of REGγ in inguinal white adipose tissue reduces HFD-induced obesity and insulin resistance.
REGγ expression is significantly increased in the adipose tissue of obese individuals and mice.
REGγ regulates browning of white adipose tissue through modulation of ACADM and KLF15 signaling.
Targeting REGγ may provide new intervention strategies for obesity management.

Chen et al. (2025) studied this question.

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