Systematic review compares probiotic treatments for atopic dermatitis in pediatric patients, suggesting implications for symptom relief.
Objective(s) Probiotics have been proposed to be effective in treating and preventing atopic diseases in pediatric patients. However, this evidence remains inconclusive, and much variability exists between studies. Atopic dermatitis is defined as a chronic, inflammatory form of eczema characterized by skin changes and has been quantitatively and qualitatively characterized by the SCORAD scale (SCOring atopic dermatitis). This project aims to compare the efficacy of various probiotic treatments (Lactobacilli, Bifidobacterium, etc.) for children with atopic dermatitis to identify if probiotic supplementation can decrease SCORAD indices in children receiving them and alleviate symptoms, and secondarily evaluate changes in immunological markers, such as IgE, with probiotic intervention. Methods Through a systematic literature review of multiple electronic databases through October 9th, 2024, we identified randomized controlled trials (RCTs) in pediatric patients with an established diagnosis of atopic dermatitis. Our search strategy was as follows: "((atopy) OR (dermatitis) OR (hypersensitivity)) AND pediatric AND probiotic" yielding 25 total studies. Patients were treated with either a probiotic regimen or placebo and assessed for levels of IgE, cytokines (CD4, CD8, IL-10, TGF-B), eosinophils, and SCORAD indices.
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Gaikwad et al. (2025) studied this question.
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