Abstract B096: Clinical trial enrollment amongst children and adolescents and young adults with primary central nervous system tumors at Columbia University Irving Medical Center

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Discussion

Logistic regression identifies age as a key factor affecting clinical trial enrollment in pediatric populations, indicating persistent disparities.

Age was identified as the primary predictor of clinical trial enrollment, with adolescents and young adults less likely to participate than children.
Among 1,005 patients, only 11% enrolled in a therapeutic trial, highlighting significant enrollment gaps for AYAs with CNS tumors.
Patients across all age groups had similar enrollment rates regardless of race/ethnicity or insurance status, suggesting broader factors may be at play.
Potential barriers for AYA enrollment may include trial availability for prevalent tumor types, emphasizing the need for targeted interventions.

McHenry et al. (2025) studied this question.

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Logistic regression identifies age as a key factor affecting clinical trial enrollment in pediatric populations, indicating persistent disparities.