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September 19, 2025Central Nervous System Agents in Medicinal Chemistry

Neuroprotective and Antioxidant Effects of Pseudoelephantopus spicatus

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Authors

SWS. WarsiAPAnwar ParvezANAbdullah Al Noman

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Overview

This study reveals antioxidant and neuroprotective effects in Pseudoelephantopus spicatus, suggesting its potential in treating neurological disorders.

Key Points

  • MEPS demonstrates significant antioxidant activity with 43.692 mg QE/g for flavonoids and behavioral improvements in stress tests.
  • Studies using Swiss albino mice show that MEPS produced dose-dependent anxiolytic and antidepressant effects at 200 mg/kg.
  • GC-MS analysis identified key phytochemicals like 9,12-octadecadienoic acid, suggesting their role in neuroprotective properties.
  • In silico docking indicates strong binding to the GABA receptor, pointing to a mechanism for the observed neuropharmacological effects.

Cite This Study

Warsi et al. (2025) studied this question.

synapsesocial.com/papers/68d43706713b0b5dfea76ee6https://doi.org/10.2174/0118715249382386250831055558
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