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September 19, 2025Molecular Nutrition & Food Research

Effects of a Probiotic Formulation Based on SF68, Phytosterols, and 6S‐5‐Methyltetrahydrofolic Acid on Body Composition, Biochemical Parameters, Gut Microbiota, and Gastrointestinal and General Symptoms of Overweight/Obese Subjects: The PrObesity Study

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Authors

GPGiuditta PagliaiSBSimone BaldiMAMarta Tristán Asensi

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Overview

Randomized trial shows that a multi-component probiotic formulation improves body composition and gut microbiota in overweight subjects, suggesting benefits for metabolic health.

Key Points

  • Probiotic treatment resulted in significant body composition improvements, including a reduction in fat mass by 1.8 kg.
  • Participants in the probiotic group had notable decreases in total cholesterol by 11 mg/dL and LDL-cholesterol by 10.3 mg/dL.
  • The gut microbiota analysis indicated improved evenness and reduced Lachnospirales abundance following probiotic intervention.
  • Gastrointestinal symptoms improved significantly in the probiotic group, suggesting enhanced gut health support.

Cite This Study

Pagliai et al. (2025) studied this question.

synapsesocial.com/papers/68d43706713b0b5dfea76c16https://doi.org/10.1002/mnfr.70198
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