September 19, 2025CancersOpen Access

Prevalence and Clinical Significance of Potential Drug–Drug Interactions in Hospitalized Pediatric Oncology Patients: A Prospective Pharmacoepidemiologic Study

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Discussion

Prospective analysis identified DDIs in hospitalized pediatric oncology, suggesting improved medication evaluation is crucial.

Approximately 21.2% of pediatric oncology patients exhibited at least one documented drug-drug interaction.
In total, 197 potential drug-drug interactions were identified, with methotrexate being the most common drug involved.
Prospective analysis of prescriptions in hospitalized patients between November 2019 and June 2020 provided critical insights into DDIs.
The study's findings highlight the need for clinical teams to routinely assess medication profiles to prevent avoidable harms.

Zekavat et al. (2025) studied this question.

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