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September 19, 2025Russian Journal of Immunology

MT1/MT2 melatonin receptors in proinflammatory T helper cell populations

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Authors

ЕКЕ. М. КуклинаIDI. Yu. DanchenkoТБТ. В. Байдина

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Overview

Research reveals a high expression of MT1 and MT2 melatonin receptors in Th1-polarized Th17 cells, suggesting a key role in autoimmune diseases.

Key Points

  • Non-classical Th1-polarized Th17 cells show significantly high levels of MT1 and MT2 receptors, indicating potent sensitivity to melatonin.
  • Melatonin binding activates signaling pathways in T cells, particularly through Gi and Gq proteins, affecting inflammation.
  • The study analyses peripheral blood proinflammatory T helper cell populations, focusing on receptor expression dynamics.
  • Understanding the role of melatonin in regulating pathogenic T helper cells may open avenues for therapeutic strategies in autoimmune diseases.

Cite This Study

Куклина et al. (2025) studied this question.

synapsesocial.com/papers/68d436fd713b0b5dfea76914https://doi.org/10.46235/1028-7221-17120-mmm
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