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September 19, 2025Cancer Epidemiology Biomarkers & Prevention

Abstract A082: Differential expression of transcriptomic pathways contributes to survival disparities between Black and White women with breast cancer

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Authors

FCFangyuan ChenAPAdrienne M. ParsonsEMElizabeth A. Mittendorf

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Overview

Longitudinal analysis reveals racial survival disparities in breast cancer, indicating immune pathways' role.

Key Points

  • NHB women showed 49% higher breast cancer-specific mortality compared to NHW women, underscoring survival disparities.
  • Cox regression revealed hazard ratios of 1.49 overall and 1.68 within specific subtypes for NHB women compared to NHW.
  • Transcriptomic profiling highlighted racial differences in immune pathways, linking these to breast cancer outcomes.
  • Adiposity and comorbidities mediated some of the differences in pathway expression, pointing to potential interventions.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d436f6713b0b5dfea765e9https://doi.org/10.1158/1538-7755.disp25-a082
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract A076: Using a counterfactual framework to understand the underlying causes of Black-White racial disparities in breast cancer mortality in the US2025
  2. 2Abstract C084: Breast tumor methylation landscape by estrogen receptor status and race using an NGS Methylation Detection System2025
  3. 3Abstract C090: Detecting epigenetic signatures to prevent avoidable racial inequities in triple-negative breast cancer (desparit): A pilot study2025
  4. 4Abstract C015: A systems biology approach to understand the racial disparities in colorectal cancer2025
  5. 5Abstract A049: Characterization of the immune tumor microenvironment and its association with cervical cancer health disparities2025