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September 19, 2025Journal of Leukocyte BiologyOpen Access

S100A9 promotes inflammasome-dependent autoinflammation by blocking the degradation of SYK tyrosine kinase

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Authors

JWJonas WolfYKYvonne KuscheFEFehime Kara Eroğlu

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Overview

Observational analysis reveals S100A9's role in inflammasome activation through SYK, suggesting novel therapeutic targets for CAPS and FMF.

Key Points

  • S100A9 regulates inflammasome activation via SYK, impacting autoinflammatory processes and cytokine secretion.
  • Loss of S100A9 impairs SYK regulation by decreasing USP10 expression, leading to increased autophagosomal degradation.
  • S100A9's role in NLRP3 activation highlights a connection between pyrin and NLRP3 in autoinflammatory diseases.
  • These findings suggest potential therapeutic avenues for conditions like CAPS and FMF, emphasizing the role of S100A9.

Cite This Study

Wolf et al. (2025) studied this question.

synapsesocial.com/papers/68d435ed713b0b5dfea76002https://doi.org/10.1093/jleuko/qiaf129
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