September 19, 2025International Journal of Gynecological Pathology

Estrogen Receptor (ER) and Progesterone Receptor (PR) Immunohistochemistry is Sensitive and Specific for Differentiating Retroperitoneal Leiomyosarcomas With Symplastic-like Features From Their Uterine Mimics

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Authors

JXJin Yan XuUniversity of Wisconsin–Madison PWPaul S. WeismanUniversity of Wisconsin–Madison

Discussion

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Implication

Analysis identifies ER and PR as key markers for distinguishing retroperitoneal leiomyosarcomas from uterine mimics, suggesting diagnostic implications.

Key Points

Immunohistochemistry for ER and PR accurately differentiates retroperitoneal LMS from uterine LM, with 100% sensitivity in the identified cohort.
All eight retroperitoneal LMS cases tested negative for ER and PR, while all six uterine LM cases expressed these receptors strongly.
Evaluation involved a cohort of 14 cases, with precise methods employed to ensure the validity of findings regarding these smooth muscle tumors.
This research supports that ER and PR stains can be crucial in accurately diagnosing retroperitoneal LMS, needing further confirmation in diverse contexts.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/68d435ed713b0b5dfea75fee https://doi.org/10.1097/pgp.0000000000001132

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Implication

Analysis identifies ER and PR as key markers for distinguishing retroperitoneal leiomyosarcomas from uterine mimics, suggesting diagnostic implications.

Estrogen Receptor (ER) and Progesterone Receptor (PR) Immunohistochemistry is Sensitive and Specific for Differentiating Retroperitoneal Leiomyosarcomas With Symplastic-like Features From Their Uterine Mimics

Discussion

Member takes

Implication

Key Points

Cite This Study

Estrogen Receptor (ER) and Progesterone Receptor (PR) Immunohistochemistry is Sensitive and Specific for Differentiating Retroperitoneal Leiomyosarcomas With Symplastic-like Features From Their Uterine Mimics

Discussion

Member takes

Implication

Key Points

Cite This Study

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