September 19, 2025European Journal of EndocrinologyOpen Access

Increased mortality in primary adrenal insufficiency: a systematic review and meta-analysis

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Mortality in patients with primary adrenal insufficiency increased significantly, with a pooled hazard ratio of 2.51.
Out of 6238 reports identified, 9 reports with a total of 13969 patients were included in the systematic review.
Observational studies on mortality compared to a reference population were assessed in this systematic analysis.
The main cause of death was cardiovascular disease, highlighting critical health concerns for these patients.

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Implication

Systematic review and meta-analysis found twofold increased mortality in adults with primary adrenal insufficiency, suggesting significant health risks.

Cite This Study

Dalakas et al. (2025) studied this question.

synapsesocial.com/papers/68d435ed713b0b5dfea75f2d https://doi.org/10.1093/ejendo/lvaf186

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Implication

Systematic review and meta-analysis found twofold increased mortality in adults with primary adrenal insufficiency, suggesting significant health risks.

Increased mortality in primary adrenal insufficiency: a systematic review and meta-analysis

Key Points

Discussion

Implication

Cite This Study

Increased mortality in primary adrenal insufficiency: a systematic review and meta-analysis

Key Points

Discussion

Implication

Cite This Study