Narrative review highlights the effects of augmented renal clearance on antibiotics and anticoagulants, suggesting implications for treatment efficacy.
Key Points
Augmented renal clearance can lead to reduced free drug concentration, impacting therapeutic outcomes and increasing treatment failure risk.
Review of 14 articles revealed that antibiotics, particularly beta-lactams and glycopeptides, are most affected by augmented renal clearance.
Study methodology included a narrative review guided by PRISMA for article selection from major databases like PubMed and Scopus.
Findings underscore the variability in clinical response of anticoagulants and anticonvulsants affected by augmented renal clearance.