September 18, 2025Nutrition Reviews

Efficacy of B Vitamin Supplementation on Global Cognitive Function in Older Adults: A Systematic Review and Meta-analysis

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A small to moderate improvement in cognitive function was noted after B vitamin supplementation among older adults.
The effect size during the analysis showed Hedges' g = 0.423, but with significant heterogeneity present across studies.
Seventeen RCTs with 5275 participants were included, indicating a diverse set of findings based on sample characteristics and study quality.
Removing statistical outliers lowered the effect size, suggesting that further refinement in study inclusion criteria is necessary.

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Systematic review and meta-analysis shows small improvement in cognitive function in older adults, indicating B vitamins may offer low-cost benefits.

Berg et al. (2025) studied this question.

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Systematic review and meta-analysis shows small improvement in cognitive function in older adults, indicating B vitamins may offer low-cost benefits.