Distinct Oxidative Stress Adaptations Driven by the Overexpression of miR-526b, miR-655, and COX-2 in Breast Cancer

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Overexpression of COX-2 significantly protects breast cancer cells against oxidative stress, decreasing apoptosis.
Cells with miR-526b and miR-655 show overlapping yet distinct responses to oxidative stress, affecting DNA damage markers.
RNA-sequencing identified key hub genes related to redox balance, immune responses, and metabolism, signaling clinical relevance.
Findings indicate miR-526b, miR-655, and COX-2 influence resistance to oxidative stress through transcriptional changes in breast cancer.

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Study reveals how miR-526b and miR-655 overexpression alters oxidative stress responses in breast cancer, suggesting potential therapeutic pathways.

Opperman et al. (2025) studied this question.

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Study reveals how miR-526b and miR-655 overexpression alters oxidative stress responses in breast cancer, suggesting potential therapeutic pathways.