September 18, 2025Open Access

Hemoglobin A1C: Intracellular Heterogeneity and Functional Implications in Prediabetic and T2 Diabetic Erythrocytes

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The study shows that intracellular HbA1C distribution varies significantly among prediabetic and diabetic individuals, impacting RBC functions.
HbA1C levels correlate strongly with other hemoglobin isoforms, including HbA0 and HbA2, in individuals with diabetes and under calcium depletion.
An investigation of the distribution of HbA1C utilized advanced methodologies to assess its functional role in red blood cells across various glycemic states.
These findings highlight the need for further research to explore the biological mechanisms underlying HbA1C's varying implications in diabetes.

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Observational analysis reveals intracellular heterogeneity of HbA1C in red blood cells, suggesting its functional implications in diabetes.

Петухова et al. (2025) studied this question.

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Observational analysis reveals intracellular heterogeneity of HbA1C in red blood cells, suggesting its functional implications in diabetes.