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September 18, 2025Frontiers in NutritionOpen Access

Association between vitamin D deficiency and risk of venous thromboembolism: a matched cohort study of 139,690 patients

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Authors

KHKuo-Chuan HungLCLi-Chen ChangCHChih‐Wei Hsu

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Overview

Matched cohort study finds vitamin D deficiency significantly raises risk of venous thromboembolism and mortality.

Key Points

  • Vitamin D deficiency is linked to a 62% higher risk of deep vein thrombosis and pulmonary embolism.
  • The study showed a significant association (HR 1.62) for both DVT and PE within one year of serum measurement.
  • Conducted as a retrospective matched cohort study using the TriNetX database with over 139,000 patients.
  • These findings suggest that optimizing vitamin D levels could aid in venous thromboembolism prevention.

Cite This Study

Hung et al. (2025) studied this question.

synapsesocial.com/papers/68d434ea713b0b5dfea74884https://doi.org/10.3389/fnut.2025.1639257
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